Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar

In the management of nonsegmental vitiligo in Madagascar, researchers evaluated outcomes obtained 10 years after the initiation of a therapeutic protocol which combines very potent topical corticosteroids (TCS), vitaminotherapy (B12 and C), and suppression of microtraumas. Included in the research were patients who agreed to follow the treatment protocol, which combined very potent TCS (two applications/day for 10 days, and then one application/day for the following 10 days), oral vitamin C 500 mg/day for 20 days, and oral vitamin B12 100 mg/day for 20 days. 

Details were evaluated for 308 patients (mean age was 33.3 years) with vitiligo. According to this prospective and descriptive study, 239 patients had excellent therapeutic compliance and attended regular follow-up. In 50 patients less than 14 years of age, excellent repigmentation was noted. In 31 patients, lesions that developed in less than 1 year had excellent treatment response. With outstanding repigmentation in 108 patients, localized lesions responded favorably to treatment. These findings indicate that therapeutic response is better for youth, lesions of less than 1 year of evolution, and for facial and neck localization of vitiligo.