Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double-blind clinical trial study

In view of the studies describing the pigmentation of iris and around the eyelid as a common side effect of latanoprost, a prostaglandin F2alpha analog employed in the treatment of glaucoma, researchers investigated the efficacy of topical latanoprost on vitiligo patches around the eyelid. They performed a randomized, double-blind, clinical trial study including 31 patients with vitiligo vulgaris and focal vitiligo involving the eyelids. Patients received either topical latanoprost gel twice daily for 12 weeks or a placebo with the same protocol. Patients treated with latanoprost exhibited a significant decrease in the symptoms of the disease, whereas those treated with placebo showed no alteration. Findings thus support the efficacy of latanoprost in treating vitiligo disease involving eyelids.

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https://onlinelibrary.wiley.com/doi/epdf/10.1111/dth.13175?referrer_access_token=ll1n25AHuLHOIlcTRsY13Ita6bR2k8jH0KrdpFOxC66p6vqq2hNBXYe7NLJtHWmvoivBBFUvgS722hvFLMqMRkgPODgB3n3OJMlyQkRLUg37n16WmN1gZoBX4ypPHIYsx9AN1Lx0f53c0814zWF5qA%3D%3D