Ginkgo biloba help protect melanocytes

Vitiligo is a common skin depigmentation disorder characterized by loss of functional melanocytes. Its pathogenesis is complex and oxidative stress plays a critical role in the development of vitiligo. Therefore, antioxidant therapy is a promising therapeutic strategy to prevent or even reverse the progression of depigmentation.

Ginkgo biloba extract has been confirmed to have protective effects on neurons against oxidative stress. In particular, several clinical studies have shown that patients with stable vitiligo achieve repigmentation after taking. However, the precise mechanism underlying the protective effects of against oxidative stress on melanocytes has not been fully elucidated.

In this study, we found that effectively protected melanocytes against oxidative stress-induced apoptosis and attenuated excessive reactive oxygen species (ROS) accumulation and lipid peroxidation by increasing the activity of antioxidative enzymes. Moreover, the antioxidative effect of was achieved by activating and its downstream antioxidative genes. In addition, interference of with siRNA abolished the protective effects of against oxidative damage on melanocytes. In conclusion, our study proves that can protect melanocytes.

Interfering with siRNA abolished the protective effects of against oxidative damage on melanocytes. In conclusion, our study proves that can protect melanocytes. Interfering with siRNA abolished the protective effects of against oxidative damage on melanocytes. In conclusion, our study proves that can protect melanocytes from oxidative stress caused by activating. Therefore, is hypothesized to be a potential therapeutic agent for vitiligo.